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Adaptimmune develops 'bionic assassins' to fight HIV

17 November 2008
Oxford-based Adaptimmune Limited has come up with a solution to fight HIV by engineering immune cells to act as "bionic assassins" that can see through the virus' many disguises.

The South East company says in its report published in the journal Nature Medicine that HIV is a master of disguise "able to rapidly change its identity" and avoid detection but with the new solution this may be a thing of the past.

According to Dr Bent Jakobsen, co-lead author of the report and Chief Scientific Officer at Adaptimmune Ltd, which owns the technology, translating the result in the clinic would place "a very powerful therapy on our hands."

"The T-cell receptor is nature's way of scanning and removing infected cells – it is uniquely designed for the job but probably fails in HIV because of the tremendous capability of the virus to mutate," he said.

"Now we have managed to engineer a receptor that is able to detect HIV's key fingerprints and is able to clear HIV infection in the laboratory."

The research, which was carried out in collaboration with the Universities of Cardiff and Pennsylvania, was partially-funded by the Wellcome Trust.ADNFCR-1584-ID-18879597-ADNFCR

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