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Genetic tinkering helps scientists tackle dengue fever

23 February 2010
Scientists in the South East have developed a new strain of mosquito which could provide the answer to dengue fever, with an Oxfordshire-based firm helping to develop a new concept for tackling the disease.

No known vaccine or treatment currently exists for Dengue fever, which is said to result in up to 100 million cases per year. With 40 per cent of the world's population said to be at risk, finding a way to tackle the virus, which causes severe flu-like symptoms, has become an important priority for pharmaceutical companies and health practitioners.

Now, researchers and scientists at Oxitec and the University of Oxford believe they may have found an innovative way to combat the dengue virus, which is spread through the bite of infected female Aedes aegypti mosquitoes.

The team have developed a strain of genetically-altered male mosquitoes who they intend to release into the wild and mate with wild females.

The next generation of female mosquitoes would be flightless, which they believe could suppress the native mosquito population, leaving the female carriers less capable of spreading the disease and less attractive to their mates.

Luke Alphey, who has worked on the project with the Oxford University spin-off firm Oxitec, said the idea offered an effective means to tackle the disease at source.

"The technology is completely species-specific, as the released males will mate only with females of the same species," he explained.

"It's far more targeted and environmentally friendly than approaches dependent upon the use of chemical spray insecticides, which leave toxic residue."

Anthony James, Distinguished Professor of microbiology & molecular genetics and molecular biology & biochemistry at the University of California, Irvine, who also worked on the study, said there was "urgent demand" for new ways of dealing with dengue fever.

"Controlling the mosquito that transmits this virus could significantly reduce human morbidity and mortality," he explained.

The results of the study have been published in the latest edition of the Proceedings of the National Academy of Sciences, with hopes that the process could be adapted to other mosquito-borne diseases such as malaria and West Nile fever.

Progress by the South East team is the latest indicator of the region's strength in the medical development and life sciences sector, with Oxfordshire being ear-marked as a so-called 'super cluster' by the government as it looks to capitalise on a highly-skilled workforce and the knowledge capital within the local universities.
ADNFCR-1584-ID-19632497-ADNFCR

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